Soft ECC® - Endocervical Curettage

Efficient.
Gentle.
Compassionate.

About Histologics

Request Samples

Our Medical Devices

Innovative solutions designed to enhance patient care and clinical outcomes in Womens Health.

SoftBiopsy ®

Single-use Kylon® pad for gentle ectocervical friction biopsy; snap-off head to fixative.

✔ Trans-epithelial

✔ Snap-off Transport

✔ Gentler than Punch

Learn More

Soft ECC ®

Blunted, tapered Kylon® tip for endocervical curettage; rotate and drop into fixative.

✔ Abundant ECC

✔ Fabric "Tissue Trap"

✔ Direct-to-fixative

Learn More

Soft ECC-S ®

Smaller, tapered Kylon® ECC device for narrow/stenotic canals.

✔ Small, Tapered Pad

✔ Fits Narrow Canals

✔ Efficient Capture

Learn More

Spirabrush ®

Spiral bristle brush for ectocervical trans-epithelial biopsy; snaps off for transport.

✔ Punch-biopsy Alt

✔ Spiral Bristle Capture

✔ Snap-off Head

Learn More

What is Kylon?

Kylon® — gentle micro-hook fabric for precise debridement and biopsy.

primer kylonc Kylon® is a patented medical fabric made of fenestrated loop “micro-hooks” woven into nylon; when lightly pressed and rotated, the hooks flex to engage epithelium, lift tissue by frictional de-bonding, and trap the sample within the fabric. It enables selective, layer-by-layer removal and specimen capture with a minimally invasive, “compassionate” technique used across women’s health (e.g., SoftBiopsy®) and wound care.

Learn More

Request Product Samples

Experience the quality and precision of our medical devices firsthand.

primer kylonc Get your sample pack from Histologics® to evaluate our devices in hand—including SoftBiopsy® and SpiraBrush® CX. Review build quality, ergonomics, and instructions with your clinical team—then choose what fits your workflow.

Request Samples

Recent Articles & Insights

Stay informed with the latest research, innovations, and best practices in gynecological care.

Histologics' Gentle Kylon® Biopsy Brush Poised to be the New Standard of Care for Endocervical Biopsy

05 May 2026 | Histologics Women's Health | Media and Press Releases

May 5, 2026 -- Anaheim, CA

Histologics LLC, based in Anaheim, California attended the Annual Meeting of the American Society of Colposcopy and Cervical Pathology in Orlando, FL from April 23-26, 2026. The meeting featured findings by the NIH showing that Histologics' Kylon® biopsy brushes enabled researchers to discover pre-malignant lesions in the endocervical canal and that carcinoma in-situ is present in the endocervix significantly more than previously thought.

NIH Global Study: Histologics Gentle Kylon® Biopsy Brush Shows Diagnostic Advantages in Cervical Cancer Workups

30 April 2026 | Histologics Women's Health | Media and Press Releases

April 30, 2026, 16:07 -- Anaheim, CA

Histologics LLC, based in Anaheim California attended the Annual Meeting of the American Society of Colposcopy and Cervical Pathology in Orlando, FL from April 23-26, 2026. Mark Schiffman MD, MPH, Epidemiologist and Senior Investigator at the National Cancer Institute / National Institutes of Health led a session addressing efficient screening, triage and treatment of diagnosed high grade cervical cancer precursors performed during the "Moonshot" funded NIH PAVE (Human Papillomavirus (HPV)-Automated Visual Evaluation) study) performed in countries with significant cervical cancer death rates: Brazil, Cambodia, Dominican Republic, El Salvador, Eswatini, Honduras, Malawi, Nigeria, and Tanzania.

Histologics, LLC to Attend ASCCP Annual Scientific Meeting in Orlando, Florida

21 April 2026 | Histologics Women's Health | Media and Press Releases

April 21, 2026, 17:00 -- Anaheim, CA

ASCCP Annual Scientific Meeting in Orlando, Florida

Histologics, LLC, the value-based leading innovator in providing devices to achieve Compassionate Colposcopy®, is excited to announce that we will be attending the upcoming American Society for Colposcopy and Cervical Pathology (ASCCP) Annual Scientific Meeting in Orlando, Florida (Renaissance Orlando at SeaWorld®) 23-25 April 2026. Being a part of this incredible community of clinicians and researchers dedicated to cervical and lower genital tract cancer prevention, diagnosis, and treatment is an honor we do not take lightly. We are especially looking forward to hearing the latest news and findings from the NIH HPV Automated Visual Evaluation (PAVE) study, presented by Mark Schiffman, MD, MPH, renowned researcher and Senior Investigator at the National Cancer Institute (NCI), National Institutes of Health.

Webinar 4: Gynecologic Pathology: Diagnostic Insights from SoftECC® Samples

16 April 2026 | Histologics Women's Health | Webinars

Webinar 3: Accurate Results in Gynecologic Pathology Start with Kylon® - Ectocervical SoftBiopsy® Practice and Pathology

14 October 2025 | Histologics Women's Health | Webinars

Compassionate Colposcopy®

22 January 2022 | Histologics Women's Health | Histologics GX

Kylon® Hooked-Fabric Biopsy Technology

Histologics LLC is proud to have developed Soft-ECC® endocervical curette, and the SoftBiopsy® exocervical gynecological biopsy device. Both devices employ a multipatented hooked fabric (Kylon®) that simultaneously biopsies with frictional raking/de-bonding of epithelium from stroma, and traps and stores the tissue for transport to the lab.

The Soft-ECC® and SoftBiopsy® were developed with the patient care experience in mind. The Soft-ECC® design is intended to fit into most endocervical canals and yield an abundant biopsy sample. The ECC procedure is usually performed to remove tissue from the endocervical canal for histological analysis during colposcopy or during the diagnostic work-up of abnormal peri-menopausal or menopausal bleeding. Unlike cytobrush sampling which is a cytologic screening modality, Soft-ECC® curettage produces diagnostic histological samples.

Webinar: A Review of Kylon®

14 October 2025 | Histologics Women's Health | Webinars

How Kylon® Removes Diagnostic Biopsy Specimens with SoftBiopsy®, Soft-ECC®

08 November 2023 | Histologics Women's Health | Resources

How Kylon® Removes Diagnostic Biopsy Specimens with SoftBiopsy®, Soft-ECC® - Video

Research Supports Compassionate New Biopsy Approach For Women's Health In Cervical Cancer Prevention

22 January 2022 | Histologics Women's Health | Media and Press Releases

(3) Mogolia; Gynecologic Research Foundation, USA 2020 - A study conducted in concert with this not for profit organization and the National Cancer Institute evaluated a rapid, high volume system to screen, biopsy, triage and when indicated, treat women at risk of harboring high grade cervical cancer precursors. A bedside rapid colposcopic imaging system and Histologics' SoftBiopsy® device was used to diagnose women at risk who underwent treatment.

Trusted by Healthcare Professionals

Hear from the medical experts who rely on our devices every day.

“The Soft-ECC rotation method assures I get a 360 degree sample with every biopsy". "The samples are abundant and diagnostic and the patients seem more comfortable than when I used the Kevorkian curette.” — Ronald Kohorn MD, Ob/Gyn

“I’m really pleased with the instruments you developed and am using them exclusively. Nice samples, not much discomfort, not too deep, and nothing to sterilize!” — Myron R. Kanofsky M.D

“I cannot say enough good things about these products. They have transformed my colposcopy practice beyond description. My patients no longer have to be in fear of having a colpo performed on them. And it's so easy to collect the specimen!! Every GYN on the planet should be using these, no decisions!!” — Sean Wengroff, MD

“I have been a long time Spirabrush CX user and like it most for the versatility of reaching lesions off the central cervix at the periphery. I like the SoftBiopsy for lesions at the center of the cervix near the os, at or inside the transformation zone. I love the Soft-ECC and occasionally still use the Kevorkian currette for stenotic cervices, but am willing to try the Soft-ECC-S for those cases” — James H. Schultz, MD, MBA, FAAFP, DiMM

“I find these soft biopsies really useful, especially when it is difficult to get a good biopsy with traditional forceps - these yield excellent tissue samples” — Simone Cox, RNNP